Sunday, September 24, 2023
  • English
  • Marathi
No Result
View All Result
Daily PRABHAT
  • Home
  • Latest News
  • National
  • International
  • Entertainment
  • Politics
  • Sports
  • Business
  • More
    • Health
    • Lifestyle
    • Technology
    • Science
Daily PRABHAT
No Result
View All Result
  • Home
  • Latest News
  • National
  • International
  • Entertainment
  • Politics
  • Sports
  • Business
  • More
Home Health

Immune system early responder can combat COVID-19

by Digital Desk
2 years ago
in Health, International
A A
Immune system early responder can combat COVID-19
Share on FacebookShare on Twitter

Washington [US] : A simple RNA molecule jump starts the immune system’s first responders to viral infection and can even eradicate the SARS-CoV-2 virus in mice with chronic cases of COVID-19, a new Yale School of Medicine study found.

The molecule, known as SLR14, is a simple, easy to manufacture, loop of RNA that can trigger the production of interferons, a group of proteins produced by immune cells that are key to the body’s innate, or initial, response to infection.
Multiple studies have shown that COVID-19 patients who produce high levels of interferons have far better outcomes than those for whom interferon levels are low during the early days of infection.

Treated mice also responded well to numerous variants of SARS-CoV-2, the virus that causes COVID-19, including the Delta variant, currently the predominant strain of the virus in the United States, according to the new report published on November 10 in the journal Experimental Medicine.

If clinical trials in humans confirm the efficacy of SLR14, the relatively inexpensive compound could help reduce COVID-19 cases in low-income countries where vaccine availability is limited, the researchers say. It can also provide important benefits for immunocompromised individuals who are not able to create sufficient levels of antibody-producing B cells and virus-killing T cells.

“SLR14 therefore holds great promise as a new class of RNA therapeutics that can be applied as antivirals against SARS-CoV-2,” said Akiko Iwasaki, the Waldemar Von Zedtwitz Professor of Immunobiology and Molecular, Cellular, and Developmental Biology at Yale and corresponding author of the paper.

Iwasaki added, “Moreover, because this RNA-based therapeutic approach is simple and versatile, our study will facilitate pandemic preparedness and response against future respiratory pathogens sensitive to Type I interferons.”

Typically, vaccines such as those that combat COVID-19 introduce harmless elements of the virus to elicit T and B cell production by the body’s adaptive immune system, which can recognize previous pathogens and mount a targeted response. Treatments such as monoclonal antibodies also aim to mimic this later-stage immune response.

For the new study, however, a team led by first author Tianyang Mao, a graduate student in Iwasaki’s lab, explored whether compounds such as SLR14 might activate the innate immune system and protect against viral infections, including COVID-19.

In experiments, the researchers found that a single dose of the compound was sufficient to protect mice against severe disease and death, worked against a variety of variants, and could even eradicate the virus from mice with chronic infections.

 

Tags: Akiko Iwasakicovid 19RNA moleculeSARS-CoV-2 virusWaldemar Von Zedtwitz ProfessorWashingtonYale School of Medicine
ShareTweetSendShareSend

Latest News

“What makes BJP leaders talk in this manner…”: Salman Khurshid on Bidhuri’s communal slurs

Uttarakhand: Police starts crackdown on drug peddlers under “Drug Free Devbhoomi 2025” campaign

“This shows BJP practices politics of hatred”: Adhir Ranjan Chowdhury on communal slurs by Ramesh Bidhuri

UAE, Indonesia reviewing strengthening economic cooperation

EAM Jaishankar, Cambodia PM hold meeting on sidelines of UNGA session 

“Women’s empowerment is inseparable part of Indian culture”: Rajnath Singh on passage of Nari Shakti Vandan Adhiniyam 

Neither Sonia Gandhi nor Mallikarjun Kharge spoke a word: Biplab Kumar Deb on Udai Bhan’s remarks

Rahul Gandhi rides pillion on girl student’s scooter in Jaipur

Ghaziabad: Girl dies after two-storey building collapses in Loni; police suspect cylinder blast

Chinese court sentences Uyghur folklorist Rahile Dawut to life imprisonment: Report 

Washington [US] : A simple RNA molecule jump starts the immune system's first responders to viral infection and can even eradicate the SARS-CoV-2 virus in mice with chronic cases of COVID-19, a new Yale School of Medicine study found. The molecule, known as SLR14, is a simple, easy to manufacture, loop of RNA that can trigger the production of interferons, a group of proteins produced by immune cells that are key to the body's innate, or initial, response to infection. Multiple studies have shown that COVID-19 patients who produce high levels of interferons have far better outcomes than those for whom interferon levels are low during the early days of infection. Treated mice also responded well to numerous variants of SARS-CoV-2, the virus that causes COVID-19, including the Delta variant, currently the predominant strain of the virus in the United States, according to the new report published on November 10 in the journal Experimental Medicine. If clinical trials in humans confirm the efficacy of SLR14, the relatively inexpensive compound could help reduce COVID-19 cases in low-income countries where vaccine availability is limited, the researchers say. It can also provide important benefits for immunocompromised individuals who are not able to create sufficient levels of antibody-producing B cells and virus-killing T cells. "SLR14 therefore holds great promise as a new class of RNA therapeutics that can be applied as antivirals against SARS-CoV-2," said Akiko Iwasaki, the Waldemar Von Zedtwitz Professor of Immunobiology and Molecular, Cellular, and Developmental Biology at Yale and corresponding author of the paper. Iwasaki added, "Moreover, because this RNA-based therapeutic approach is simple and versatile, our study will facilitate pandemic preparedness and response against future respiratory pathogens sensitive to Type I interferons." Typically, vaccines such as those that combat COVID-19 introduce harmless elements of the virus to elicit T and B cell production by the body's adaptive immune system, which can recognize previous pathogens and mount a targeted response. Treatments such as monoclonal antibodies also aim to mimic this later-stage immune response. For the new study, however, a team led by first author Tianyang Mao, a graduate student in Iwasaki's lab, explored whether compounds such as SLR14 might activate the innate immune system and protect against viral infections, including COVID-19. In experiments, the researchers found that a single dose of the compound was sufficient to protect mice against severe disease and death, worked against a variety of variants, and could even eradicate the virus from mice with chronic infections.  
No Result
View All Result
  • Home
  • Latest News
  • National
  • International
  • Entertainment
  • Politics
  • Sports
  • Business
  • More
    • Health
    • Lifestyle
    • Technology
    • Science